Is there a difference between maternal antibodies and antibodies from vaccines or natural disease?

The reason for the increase in antibody titer from the subsequent vaccination is due to the specificity of the acquired immune response.

Memory B cells, which play the role of producing antibodies, are still foreign to the antigen at the first exposure, so their recall and production of antibody titer and antibody quality are not desirable, but in the second exposure, this memory, since it has already been formed, acts completely specific and will be stimulated with a minimum of antigen or immunogen (although a portion of the vaccine will be neutralized).

The second dose significantly increases the level of highly specific memory B cells.

As a result, the number of antibodies will be greater, the antibody will have greater high affinity Ab maturity and longer durability.

Interestingly, if, for example, the first vaccine is used live and the second vaccine is killed (prime boost), this effect will be even greater.

Combining different vaccine types can elicit a broader and more potent immune response compared to using a single vaccine type.

However, maternal antibodies neutralize the vaccine based on their quantity and number in the first days, and the higher the HI, the more they neutralize the vaccine's immunogenic epitopes. However, because they do not have the support of the producing cell and because they do not have high specificity, their lifespan is short, so they are quickly destroyed.